Welcome to the Future of Cell Monitoring
Transform your Cell Monitoring process with our label-free fully non-invasive imaging system.
OCTiCell™ enables label-free measurement of cell size, concentration and viability of suspended cells in bioreactors and sealed containers while preserving cell integrity and sterility. Designed for continuous, real-time, in-line monitoring, and in-place measurements.
How OCTiCell™ Works
Powered by Optical Coherence Tomograph (OCT), OCTiCell monitors suspended cells directly through the transparent wall of a bioreactor or sealed vessels. A fixed optical beam detects cells as they move through the measurement region, and the system analyzes their backscattered light to determine cell concentration, size and viability.
Benefits of OCTiCell™
Non-Invasive: No probes inserted into the culture, no risk of contamination
No consumables: 100% label-free approach
No sample loss: Safe NIR probe
Reduced Labor cost: No more manual subsampling
Continuous: 24/7 automated measurements
Compatible: Works with any clear-walled bioreactor or vials.
Reliable: Same or better accuracy than industry standard offline cell counter
Application
Continuous Cell Monitoring, Less Manual Sampling
Designed for next-generation cell manufacturing, OCTiCell™ supports Process Analytical Technology (PAT) and Quality by Design (QbD) initiatives by providing continuous, real-time insight into critical cell culture parameters. The platform tracks cell viability, concentration, and morphological changes directly within sealed containers and bioreactors, enabling process optimization, enhanced control, and continuous verification throughout the cell culture lifecycle.
Continuous Monitoring Workflow
Continuous Monitoring Across a 14-Day Culture Run
Stop planning your cell-counting schedule around evenings, weekends, and staff availability. Automated measurements at user-defined intervals reduce the need for repeated manual sampling and scheduled lab visits.
See what happens between the sampling points.
Continuous measurements reveal growth trends and culture changes that periodic offline snapshots can miss.
Software Interface for Cell Monitoring
OCTiCell cell monitoring software enables automated, continuous monitoring of mammalian cell culture. Once a capture is initiated, the system repeatedly acquires and analyzes images at the user-defined intervals, generating real-time trends for cell concentration, viability, and size. The monitoring dashboard allows users to follow culture progression over time and review growth behavior without repeated manual measurement.
For Fill & Finish
Designed for next-generation cell manufacturing, OCTiCell™ extends real-time cell analytics to fill & finish operations by providing rapid, non-invasive assessment of critical cell quality attributes. The platform measures cell viability, concentration, and size directly within sealed vials and final containers, eliminating the need for sampling or product manipulation. This enables streamlined workflows, preserved sterility, and efficient verification of final product quality prior to release.
OCTiCell Fill & Finish Workflow
OCTiCell provides viability measurements that closely match conventional offline methods.
Across the full viability range tested, OCTiCell demonstrated high accuracy and excellent agreement with reference offline measurements, enabling reliable real-time viability monitoring without the need for destructive sampling.
Software Interface
OCTiCell Fill & Finish software provides a streamlined workflow for calibration, samples measurement, and data management. Users can create and manage cell and vial specific calibrations, configure new measurements, automatically capture and analyze samples for cell concentration, viability and size. Measurement and calibration records can be reviewed, filtered and exported for further analysis and documentation.
OCTiCell™ Specifications
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OCTiCell™ Specifications |
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Working Range |
5×104 to 1*107 |
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Cell Type |
Mammalian cells HEK293, Jurkat T-Cell, CHO and more |
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Cell Size Range |
>10 μm |
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Vial/Bioreactor Type |
Clear, non-translucent glass or plastic |
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Sample Volume Recommendation |
1 ml (vial) |
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Data Output (Fill & Finish) |
Concentration, Viability (%), Average Size |
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Data Output (Continuous Monitoring) |
Concentration, Granularity, Average Size |
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Measure Speed |
≤35sec |
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Cell Concentration Accuracy |
+/- 10% |
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Mean Size Measurement Accuracy |
+/- 1.5 μm |
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Cell Viability Accuracy |
+/- 11% |
System Dimension
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Weight |
20.4 lb. |
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Dimension (W x H x L) |
21.6 x 53.3 x 40.6 cm |
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Probe Dimension |
18 x 18 x 39mm |
